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Ингредиенты

Чага.
Входит в состав банки «Энергия».

Чага, пожалуй, наиболее лекарственный древесный гриб наших лесов. Обладает мощной противораковой, антиоксидантной, противовирусной, иммуномодулирующей и общеадаптогенной активностью, поддерживает работу мозга и ЖКТ. Чага является энергетиком аналогично кордицепсу. Важно, что чага эффективно разжижает кровь и не даёт слипаться эритроцитам.

Перечень научных исследований
подтверждающих эффективность ингредиента

Alzand K. I. et al. Lanostane-Type Triterpenes and Abietane-Type Diterpene from the Sclerotia of Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), and Their Biological Activities // Int. J. Med. Mushrooms. 2018. 20(6):507–516.

Arata S. et al. Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice // Heliyon. 2016. 2(5).

Baek J. et al. Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells // J. Ethnopharmacol. 2018. 224:63–75.

Bal T. L. et al. Influence of Chaga (Inonotus obliquus) treatment of wood in decay tests // Current Research in Environmental & Applied Mycology. 2019. 9(1):85–91.

Balandaykin M. E., Zmitrovich I. V. Review on Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes): Realm of Medicinal Applications and Approaches on Estimating its Resource Potential // Int. J. Med. Mushrooms. 2015. 17(2):95–104.

Blagodatski A. et al. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy // Oncotarget. 2018. 9(49):29259–29274.

Burczyk J. et al. Antimitotic activity of aqueous extracts of Inonotus obliquus // J. Ethnopharmacol. 2009. 121(2):221–228.

Burmasova M. A. et al. Melanins of Inonotus Obliquus: Bifidogenic and Antioxidant Properties // Biomolecules. 2019. 9(6):248.

Chen H.‑J. et al. The Increase of Bioactive Ingredients by Solid State Fermentation of Inonotus obliquus with Spent Substrate // Waste and Biomass Valorization. 2019. 11:6725–6739.

Chung M. J. et al. Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells // Nutrition Research and Practice. 2010. 4(3):177–182.

Cui Y. et al. Antioxidant effect of Inonotus obliquus // J. Ethnopharmacol. 2005. 96(1–2):79–85.

Debnath T. et al. Anti-oxidant and anti-inflammatory activities of Inonotus obliquus and germinated brown rice extracts // Molecules. 2013. 18:9293–9304.

Du X. et al. Chemical analysis and antioxidant activity of polysaccharides extracted from Inonotus obliquus sclerotia // Int. J. Biol. Macromol. 2013. 62:691–696.

Duru K. C. et al. The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies // Phytotherapy Research. 2019. 33(8):1966–1980.

Fradj N. et al. RNA-Seq de Novo Assembly and Differential Transcriptome Analysis of Chaga (Inonotus obliquus) Cultured with Different Betulin Sources and the Regulation of Genes Involved in Terpenoid Biosynthesis // Int. J. Mol. Sci. 2019. 20:4334(1–27).

Géry A. et al. Chaga (Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B) // Integr. Cancer Ther. 2018. 17(3):832–843.

Gil Y.-G. et al. Synthesis of porous Pd nanoparticles by therapeutic chaga extract for highly efficient tri-modal cancer treatment // Nanoscale. 2018. 10:19810–19817.

Giridharan V. V. et al. Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus — a medicinal mushroom // Food. Funct. 2011. 2(6):320–327.

Giridharan V. V. et al. 3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice // Cells. 2020. 9(3):597.

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Ham S. S. et al. Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract // Mutat. Res. 2009. 672(1):55–59.

Han Y. et al. Inonotus obliquus polysaccharides protect against Alzheimer's disease by regulating Nrf2 signaling and exerting antioxidative and antiapoptotic effects // Int. J. Biol. Macromol. 2019. 131:769–778.

Harikrishnan R. et al. Inonotus obliquus containing diet enhances the innate immune mechanism and disease resistance in olive flounder Paralichythys olivaceus against Uronema marinum // Fish & Shellfish Immunology. 2012. 32:1148–1154.

Hu Y. et al. Antioxidant activity of Inonotus obliquus polysaccharide and its amelioration for chronic pancreatitis in mice // Int. J. Biol. Macromol. 2016. 87:348–356.

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Hwang A. Y. et al. Effects of non-traditional extraction methods on extracting bioactive compounds from chaga mushroom (Inonotus obliquus) compared with hot water extraction // LWT — Food Science and Technology. 2019. 110:80–84.

Jarosz A. et al. Effect of the extracts from fungus Inonotus obliquus on catalase level in HeLa and nocardia cells // Acta Biochim. Pol. 1990. 37(1):149–151.

Javed S. et al. Inonotus obliquus attenuates histamineinduced microvascular inflammation // PLoS ONE. 2019. 14(8):e0220776.

Jiang Sh. et al. Inonotus Obliquus Polysaccharides Induces Apoptosis of Lung Cancer Cells and Alters Energy Metabolism via the LKB1/AMPK Axis // Int. J. Biol. Macromol. (Journal Pre-proofs). 2019. 46(2):167–72.

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Kahlos K. et al. Antitumor activity of triterpenes in Inonotus obliquus // Planta Med. 1986. 52(6):554.

Kahlos K. et al. Antitumor tests of inotodiol from the fungus Inonotus obliquus // Acta Pharm. Fenn. 1986. 95:173–177.

Kahlos K. et al. Antitumor activity of some compounds and fractions from an n-hexane extract of Inonotus obliquus // Acta Pharm. Fenn. 1987. 96:33–40.

Kahlos K. et al. Preliminary studies on the antitumor activity of polar fractions extracted from Inonotus obliquus // Acta Pharm. Fenn. 1987. 96:167–174.

Kim H. G. et al. Ethanol extract of Inonotus obliquus inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells // J. Med. Food. 2007. 10(1):80–89.

Kim J.-H. et al. γ-Irradiation Improves the Color and Antioxidant Properties of Chaga Mushroom Inonotus obliquus) Extract // J. Med. Food. 2009. 12(6):1343–1347.

Kim Y. O. et al. Immuno-stimulating effect of the endopolysaccharide produced by submerged culture of Inonotus obliquus // Life Sciences. 2005. 77(19):2438–2456.

Kim Y. O. et al. Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus // Life Sciences. 2006. 79(1):72–80.

Kukulyanskaya T. A. et al. Physicochemical properties of melanins produced by the sterile form of Inonotus obliquus ("Chagi") in natural and cultivated fungus // Appl. Biochem. Microbiol. 2002. 38(1):58–61.

Lee I. K. et al. New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus // Bioorg. Med. Chem. Lett. 2007. 17(24):6678–6681.

Lee J.-H., Hyun Ch.-K. Insulin-Sensitizing and Beneficial Lipid-Metabolic Effects of the Water-Soluble Melanin Complex Extracted from Inonotus obliquus // Phytother. Res. 2014. 28:1320–1328.

Lee K. et al. Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9 // Int. J. Oncol. 2014. 45(6):2533–2540.

Lee K. R. et al. Polysaccharide isolated from the liquid culture broth of Inonotus obliquus suppresses invasion of B16‑F10 melanoma cells via AKT/NF-κB signaling pathway // Molecular Medicine Reports. 2016. 14(5):4429–4435.

Lee M. J. et al. Physicochemical Properties of Chaga (Inonotus obliquus) Mushroom Powder as Influenced by Drying Methods // J. Food Sci. Nutr. 2007. 12(1):40–45.

Lee S. H. et al. Antitumor Activity of Water Extract of a Mushroom, Inonotus obliquus, against HT-29 Human Colon Cancer Cells // Phytother. Res. 2009. 23(12):1784–1789.

Liu P. et al. Structure Characterization and Hypoglycaemic Activities of Two Polysaccharides from Inonotus obliquus // Molecules. 2018. 23(8):1948.

Mazurkiewicz W. Analysis of aqueous extract of Inonotus obliquus // Acta Pol. Pharm. 2006. 63(6):497–501.

Mazurkiewicz W. et al. Separation of an aqueous extract Inonotus obliquus (Chaga). A novel look at the efficiency of its influence on proliferation of A549 human lung carcinoma cells // Acta Pol. Pharm. 2010. 67(4)397–406.

Mu H. et al. Antioxidative Properties of Crude Polysaccharides from Inonotus obliquus // Int. J. Mol. Sci. 2012. 13:9194–9206.

Najafzadeh M. et al. Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease // Biofactors. 2007. 31(3–4):191–200.

Nakajima Y. et al. Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga) // Chem. Pharm. Bull. (Tokyo). 2007. 55(8):1222–1226.

Nakamura S. et al. New bioactive triterpene constituents from Inonotus obliquus // Journal of the Pharmaceutical Society of Japan. 2007. 127:58–60.

Nakata T. et al. New Lanostane Triterpenoids, Inonotsutriols D, and E from Inonotus obliquus // Bulletin of Osaka University of Pharmaceutical Sciences. 2009. 4(3):328–332

Niu H. et al. Investigation of three lignin complexes with antioxidant and immunological capacities from Inonotus obliquus // Int. J. Biol. Macromol. 2016. 86:587–593.

Parfenov A. A. et al. Hepatoprotective Effect of Inonotus obliquus Melanins: In Vitro and In Vivo Studies // BioNanoScience. 2019. 9:528–538.

Park J. R. et al. Reversal of the TPA-induced inhibition of gap junctional intercellular communication by Chaga mushroom (Inonotus obliquus) extracts: effects on MAP kinases // Biofactors. 2006. 27(1–4):147–155.

Park Y. K. et al. Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay // Biofactors. 2004. 21(1–4):109–112.

Park Y. M. et al. In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus // J. Ethnopharmacol. 2005. 101(1–3):120–128.

Pisha E. Method for selectivity inhibiting melanoma, using betulinic acid // Nat. Med. 1995. 1:1046–1051.

Sagayama K. et al. Lanostane‑type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells // J. Nat. Med. 2019. 73(3):597–601.

Shahzad F. et al. The Antiviral, Anti-Inflammatory Effects of Natural Medicinal Herbs and Mushrooms and SARS-CoV-2 Infection // Nutrients. 2020. 12(9):2573.

Song Y. et al. Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides // Curr. Microbiol. 2008. 57(5):454–462.

Staniszewska J. et al. Antitumor and immunomodulatory activity of Inonotus obliquus // Herba Polonica. 2017. 63(2):48–58.

Sun J. E. et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice // J. Ethnopharmacol. 2008. 118(1):7–13.

Sung B. et al. Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB // Mol. Cancer Ther. 2008. 7(1):191–201.

Sysoeva M. A. et al. Comparison of the antioxidant activity of aqueous and ethanolic extracts from chaga (Inonotus obliquus) // Russian Journal of Bioorganic Chemistry. 2010. 36(7):947–950.

Szymański M. et al. An investigation into the relationships between antioxidant activity and chemical elements as well as polyphenolics in fungal fruiting bodies growing on Betula L. // J. Elem. 2019. 24(1):193–205.

Taji S. et al. Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity // Eur. J. Med. Chem. 2008. 43(11):2373–2379.

Tian J. et al. Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses // Int. J. Biol. Macromol. 2017. 95:160–167.

Tsai C. C. et al. Inonotus obliquus extract induces apoptosis in the human colorectal carcinoma’s HCT-116 cell line // Biomed. Pharmacother. 2017. 96:1119–1126.

Vamanu E. et al. Characterization of some bioactive compounds released by Inonotus obliquus in submerged culture // Scientific Bulletin. Series F. Biotechnologies. 2018. XXII:217–220.

Van Q. et al. Anti-inflammatory effect of Inonotus obliquus, Polygala senega L., and Viburnum trilobum in a cell screening assay // J. Ethnopharmacol. 2009. 125:487–493.

Wang C. et al. Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice // Food and Chemical Toxicology. 2017. 108:498–509.

Wang M. et al. Simultaneous Use of Stimulatory Agents to Enhance the Production and Hypoglycaemic Activity of Polysaccharides from Inonotus obliquus by Submerged Fermentation // Molecules. 2019. 24(23):4400.

Wu Y. Inonotus obliquus extract alleviates myocardial ischemia/reperfusion injury by suppressing endoplasmic reticulum stress // Mol. Med. Rep. 2021. 23(1):77.

Xu L. et al. Inonotus obliquus polysaccharide protects against adverse pregnancy caused by Toxoplasma gondii infection through regulating Th17/Treg balance via TLR4/NF-κB pathway // Int. J. Biol. Macromol. (Journal Pre-proofs). 2019. 146:832–840.

Xu X. et al. Comparative antioxidative characteristics of polysaccharide-enriched extracts from natural sclerotia and cultured mycelia in submerged fermentation of Inonotus obliquus // Food Chem. 2011. 127:74–79.

Zhang C.-J. Spatial structure and anti-fatigue of polysaccharide from Inonotus obliquus // Int. J. Biol. Macromol. 2020. 151:855–860.

Zhang L. et al. Immunopotentiating effect of Inonotus obliquus fermentation products administered at vaccination in chickens // Molecular and Cellular Probes. 2019. 41:43–51.

Zhang S.-D. et al. Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells // Phytomedicine. 2019. 60:152957.

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Zhao F. et al. Chemical constituents from Inonotus obliquus and their antitumor activities // J. Nat. Med. 2016. 70:721–730.

Zheng W. et al. Analysis of Antioxidant Metabolites by Solvent Extraction from Sclerotia of Inonotus obliquus (Chaga) // Phytochem. Anal. 2011. 22:95–102.

Zheng W. et al. Production of antioxidant and antitumor metabolites by submerged cultures of Inonotus obliquus cocultured with Phellinus punctatus // Appl. Microbiol. Biotechnol. 2011. 89:157–167.

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