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Ингредиенты

Ежовик гребенчатый.
Входит в состав банки «Адаптоген».

Ежовик гребенчатый — один из немногих непсихоактивных грибов, обладающих ноотропными и антидепрессантными свойствами. Также гриб замедляет процессы старения, повышает общую выносливость и обладает противораковой активностью. Ежовик поддерживает и восстанавливает работу мозга и нервной системы, улучшает когнитивные функции, устраняет вирусные повреждения нервных клеток и эффект демиелинизации, эффективен при болезнях Альцгеймера и Паркинсона. Согласно научным исследованиям 2021 года, ежовик гребенчатый рекомендован для профилактики коронавирусной инфекции и устранения последствий воздействия COVID-19 на бронхолёгочную систему.

Перечень научных исследований
подтверждающих эффективность ингредиента

Abdulla M. A. et al.Potential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats // Int. J. Med. Mushrooms. 2011. 13(1):33–39.

Abdullah N. et al. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities // Evid. Based Complement. Alternat. Med. 2012. 2012:464238.

Bailly C., Gao J. M. Erinacine A and related cyathane diterpenoids: Molecular diversity and mechanisms underlying their neuroprotection and anticancer activities // Pharmacol. Res. 2020. 159:104953.

Brandalise F. et al. Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice // Evid. Based Complement. Alternat. Med. 2017. 2017:3864340.

Chen B. et al. Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus // Planta Med. 2020. 86(8):571–578.

Chen P. et al. Comparison of antioxidant and antiproliferation activities of polysaccharides from eight species of medicinal mushrooms // Int. J. Med. Mushrooms. 2015. 17(3):287–295.

Chen W. et al. Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats // Int. J. Biol. Macromol. 2020. 159:948–956.

Cheng J. H. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity // BMC Complement. Altern. Med. 2016. 16:170.

Chiu C. H. et al. Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice // Int. J. Mol. Sci. 2018. 19(2):341.

Chong P. S. Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia // Sci. Rep. 2020. 10(1):14945.

Chong P. S. et al. Therapeutic Potential of Hericium erinaceus for Depressive Disorder // Int. J. Mol. Sci. 2019. 21(1):163.

Cui F. Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02 // Curr. Microbiol. 2016. 73(3):379–385.

Diling C. et al. Docking Studies and Biological Evaluation of a Potential β-Secretase Inhibitor of 3-Hydroxyhericenone F from Hericium erinaceus // Front. Pharmacol. 2017. 8:219.

Diling C. et al. Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota // Oncotarget. 2017. 8(49):85838–85857.

Diling C. et al. Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota // Front. Immunol. 2017. 8:666.

Ellan K. Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study // BMC Complement. Altern. Med. 2019. 19(1):260.

Han Z. H. et al. Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides // Int. J. Biol. Macromol. 2021. 52:66–71.

Hetland G. Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifolafrondosa: A Review of Preclinical and Clinical Studies // Nutrients. 2020. 12(5):1339.

Hetland G. et al. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? // Scand. J. Immunol. 2021. 93(1):e12937.

Hiraki E. Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds // J. Nat. Med. 2017. 71(3):482–491.

Hiwatashi K. et al. Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet // Biosci. Biotechnol. Biochem. 2010. 74(7):1447–1451.

Hou X. X. Fruiting body polysaccharides of Hericium erinaceus induce apoptosis in human colorectal cancer cells via ROS generation mediating caspase-9-dependent signaling pathways // Food Funct. 2020. 11(7):6128–6138.

Hou Y. et al. Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus // Mol. Med. Rep. 2015. 11(5):3794–3799.

Jang H. J. et al. The Neuroprotective Effect of Hericium erinaceus Extracts in Mouse Hippocampus after Pilocarpine-Induced Status Epilepticus // Int. J. Mol. Sci. 2019. 20(4):859.

Jiang S. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals // Appl. Microbiol. Biotechnol. 2014. 98(18):7661–7670.

Kim S. Hericium erinaceus isolectins recognize mucin-type O-glycans as tumor-associated carbohydrate antigens on the surface of K562 human leukemia cells // Int. J. Biol. Macromol. 120(Pt A):1093–1102.

Kim S. P. Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice // J. Agric. Food Chem. 2011. 59(18):9861–9869.

Kim S. P. Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice // J. Agric. Food Chem. 2013. 61(20):4898–4904.

Kim S. P. et al. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells // J. Agric. Food Chem. 2012. 60(22):5590–5596.

Kim Y. O. Hericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages // Immunopharmacol Immunotoxicol. 2012. 34(3):504–512.

Kolotushkina E. V. et al. The influence of Hericium erinaceus extract on myelination process in vitro // Fiziol. Zh. 2003. 49(1):38–45.

Komiya Y. et al. Increase in muscle endurance in mice by dietary Yamabushitake mushroom (Hericium erinaceus) possibly via activation of PPARδ // Anim. Sci. J. 2019. 90(6):781–789.

Kuo H. C. et al. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade // J. Transl. Med. 19(1):67.

Lee J. S., Hong E. K. Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells // Cancer Lett. 2010. 297(2):144–154.

Lee K. F. et al. Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson's Disease // Antioxidants (Basel). 2020. 9(2):137.

Li I. C. et al. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines // Behav. Neurol. 2018. 2018:5802634.

Li I. C. et al. Erinacine A-enriched Hericium erinaceus mycelia promotes longevity in Drosophila melanogaster and aged mice // PLoS One. 2019. 14(5):e0217226.

Li I. C. et al. (Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Stud // Front Aging Neurosci. 2020. 12:155.

Liang B. et al. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats // BMC Complement. Altern. Med. 2013. 13:253.

Limanaqi F. Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea // Antioxidants (Basel). 2020. 9(3):234.

Liu J. et al. Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus // Exp. Ther. Med. 2015. 9(2):483–487.

Liu J. H. et al. (2016) Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus // J. Ethnopharmacol. 2016. 183:54–58.

Liu J. Y. Isolation and structural characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its arrest of cell cycle at S-phage in colon cancer cells // Int. J. Biol. Macromol. 2020. 157:288–295.

Liu X. et al. Structural characterization of enzymatic modification of Hericium erinaceus polysaccharide and its immune-enhancement activity // Int. J. Biol. Macromol. 2021. 166:1396–1408.

Mori K. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial // Phytother. Res. 2009. 23(3):367–372.

Mori K. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation // Phytomedicine. 2010. 17(14):1082–1085.

Mori K. Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice // Biomed. Res. 2011. 32(1):67–72.

Mori K. et al. Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice // Biomed. Res. 2011. 32(1):67–72.

Phan C. W. et al. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism // Crit. Rev. Biotechnol. 2015. 35(3):355–368.

Qin T. et al. Characterization of polysaccharides isolated from Hericium erinaceus and their protective effects on the DON-induced oxidative stress // Int. J. Biol. Macromol. 2020. 152:1265–1273.

Rahman M. M. Chondroprotective Effects of a Standardized Extract (KBH-JP-040) from Kalopanax pictus, Hericium erinaceus, and Astragalus membranaceus in Experimentally Induced In Vitro and In Vivo Osteoarthritis Models // Nutrients. 2018. 10(3):356.

Ratto D. et al. Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging // Nutrients. 2019. 11(4):715.

Ryu S. et al. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain // J. Med. Food. 2018. 21(2):174–180.

Saitsu Y. Improvement of cognitive functions by oral intake of Hericium erinaceus // Biomed. Res. 2019. 40(4):125–131.

Sangtitanu T. et al. Peptides obtained from edible mushrooms: Hericium erinaceus offers the ability to scavenge free radicals and induce apoptosis in lung cancer cells in humans // Food Funct. 2020. 11(6):4927–4939.

Sheng X. et al. Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology // Food Funct. 2017. 8(3):1020–1027.

Trovato A. et al. Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer's disease pathogenesis // Immun. Ageing. 2016. 13:23.

Tsai Y. C. et al. Hericium erinaceus Mycelium and Its Isolated Compound, Erinacine A, Ameliorate High-Fat High-Sucrose Diet-Induced Metabolic Dysfunction and Spatial Learning Deficits in Aging Mice // J. Med. Food. 2019. 22(5):469–478.

Tsai-Teng T. et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice // J. Biomed. Sci. 2016. 23(1):49.

Tzeng T. T. et al. The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer's Disease-Related Pathologies in APP/PS1 Transgenic Mice // Int. J. Mol. Sci. 2018. 19(2):598.

Üstün R., Ayhan P. Regenerative activity of Hericium erinaceus on axonal injury model using in vitro laser microdissection technique // Neurol. Res. 2019. 41(3):265–274.

Vigna L. Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? // Evid. Based Complement. Alternat. Med. 2019. 2019:7861297.

Wang D. Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota // J. Food Sci. 2020. 85(6):1872–1890.

Wang D. et al. A polysaccharide from cultured mycelium of Hericium erinaceus relieves ulcerative colitis by counteracting oxidative stress and improving mitochondrial function // Int. J. Biol. Macromol. 2019. 125:572–579.

Wang L. Y. Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS // Molecules. 2019. 24(18):3317.

Wang M. et al. A unique polysaccharide purified from Hericium erinaceus mycelium prevents oxidative stress induced by H2O2 in human gastric mucosa epithelium cell // PLoS One. 2019. 12(7):e0181546.

Winder M. The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology // Acta Pharm. 2021. 71(1):1–16.

Winder M. The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology // Acta Pharm. 2021. 71(1):1–16.

Wong K. H. Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review) // Int. J. Med. Mushrooms. 2012. 14(5):427–446.

Wong K. H. Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration // Chin. J. Integr. Med. 2016. 22(10):759–767.

Wu F. et al. Structure characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its immunomodulatory activities // Food Funct. 2018. 9(1):294–306.

Yang B. K. et al. Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus // Biosci. Biotechnol. Biochem. 2003. 67(6):1292–1298.

Yang P. P. et al. Effects of Hericium erinaceus Mycelium Extracts on the Functional Activity of Purinoceptors and Neuropathic Pain in Mice with L5 Spinal Nerve Ligation // Evid. Based Complement. Alternat. Med. 2020. 2020:2890194.

Yang Y. et al. The Prebiotic Activity of Simulated Gastric and Intestinal Digesta of Polysaccharides from the Hericium erinaceus // Molecules. 2018. 23(12):3158.

Yi Z. et al. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan–Induced Diabetic Neuropathic Pain in Rats. Evid. Based Complement // Alternat. Med. 2015. 2015:595480.

Zan X. Hericium erinaceus polysaccharide–protein HEG–5 inhibits SGC–7901 cell growth via cell cycle arrest and apoptosis // Int. J. Biol. Macromol. 2015. 76:242–253.

Zhang C. C. Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway // Int. J. Mol. Sci. 2017. 18(8):1659.

Zhang C. et al. Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice // Sci. Rep. 2017. 7(1):10847.

Zhang J. et al. (2016) The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer's Disease Mouse Model. Int. J. Mol. Sci. 17(11):1810.

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