Ингредиенты

Рейши — древнейший лекарственный гриб с выраженными адаптогенными свойствами. Показан к постоянному применению для поддержания здоровья в любом возрасте. Оказывает системное благотворное влияние в плане общего улучшения самочувствия, нормализации большинства физиологических процессов, работает как адаптоген (снижает уровень стресса), повышает выносливость и снижает усталость. Рейши показан при заболеваниях сердечно-сосудистой системы и ЖКТ, мигренях, расстройствах сна, вегетососудистой дистонии, состоянии после перенесённого инсульта и инфаркта, обладает противовирусной, антибактериальной, антиоксидантной, иммуномодулирующей, антиаллергенной активностью, очищает печень и почки, повышает когнитивные функции, эффективен при болезнях Альцгеймера и Паркинсона. В 2021 году для рейши официально подтверждена прямая активность против COVID-19.

Перечень научных исследований
подтверждающих эффективность ингредиента

Abate M. et al. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury // Pharmaceuticals (Basel). 2020. 13(9):224.

Aydin S. et al. Effects of Ganoderma lucidum on obstructive jaundice-induced oxidative stress // Asian J Surg. 2010. 33(4):173–180.

Batbayar S. et al. Medicinal mushroom Lingzhi or Reishi, Ganoderma lucidum (W.Curt.:Fr.) P. Karst., beta-glucan induces Toll-like receptors and fails to induce inflammatory cytokines in NF-kappaB inhibitor-treated macrophages // Int J Med Mushrooms. 2011. 13(3):213–225.

Berger A et al. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs // Lipids Health Dis. 2004. 3:2.

Bharadwaj S. et al. Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease // Sci Rep. 2019. 9(1):19059.

Blum K et al. DNA based customized nutraceutical "gene therapy" utilizing a genoscore: a hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human // Med Hypotheses. 2006. 66(5):1008–1018.

Cai Q. et al. Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response // J Neuroinflammation. 2017. 14(1):63.

Calviño E. et al. Cytotoxic action of Ganoderma lucidum on interleukin-3 dependent lymphoma DA-1 cells: involvement of apoptosis proteins // Phytother Res. 2011. 25(1):25–32.

Carrieri R. et al. Structural data and immunomodulatory properties of a water-soluble heteroglycan extracted from the mycelium of an Italian isolate of Ganoderma lucidum // Nat Prod Res. 2017 31(18):2119–2125.

Çelik B., Özparlak H. Determination of genotoxic and antigenotoxic effects of wild-grown Reishi mushroom (Ganoderma lucidum) using the hen's egg test for analysis of micronucleus induction // Biotech Histochem. 2019. 94(8):628–636.

Chang C. J. et al. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin // Innate Immun. 2014. 20(3):301–311.

Chen J. et al. Protective roles of polysaccharides from Ganoderma lucidum on bleomycin-induced pulmonary fibrosis in rats // Int J Biol Macromol. 2016. 92:278–281.

Chen L. H. et al. Ganoderma lucidum polysaccharides reduce methotrexate-induced small intestinal damage in mice via induction of epithelial cell proliferation and migration // Acta Pharmacol Sin. 2011. 32(12):1505–1512.

Chen M. et al. Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rat // Int J Biol Macromol. 2020. 155:890–902.

Chen P. et al. Comparison of antioxidant and antiproliferation activities of polysaccharides from eight species of medicinal mushrooms // Int J Med Mushrooms. 2015. 17(3):287–295.

Chen Q et al. Study on genes with altered expression in alpha-amanitin poisoned mice and evaluation on antagonistic effects of traditional Chinese medicines against toxicity of alpha-amanitin // Acta Biol Hung. 2009. 60(3):281–291.

Chen W. Y et al. Effect of Reishi polysaccharides on human stem/progenitor cells // Bioorg Med Chem. 2010. 18(24):8583–8591.

Chen X. et al. Gano oil: A novel antinociceptive agent extracted from Ganoderma lucidum inhibits paw oedema and relieves pain by hypnotic and analgesic actions of fatty acid amides // J Ethnopharmacol. 2020. 263:113144.

Cheng A. Y. et al. Water-Extracted Ganoderma lucidum Induces Apoptosis and S-Phase Arrest via Cyclin-CDK2 Pathway in Glioblastoma Cells // Molecules. 2020. 25(16):3585.

Cheng C. H. et al. The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells // Nutr Cancer. 2019. 62(5):648–658.

Chiu H. F. et al. Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers // Pharm Biol. 2017. 55(1):1041–1046.

Choi Y. J et al. Anti-Amnesic Effect of Fermented Ganoderma lucidum Water Extracts by Lactic Acid Bacteria on Scopolamine-Induced Memory Impairment in Rats // Prev Nutr Food Sci. 2015. 20(2):126–132.

Chu C. L. et al. A novel adjuvant Ling Zhi-8 for cancer DNA vaccines // Hum Vaccin. 2011. 7(11):1161–1164.

Chu T. T et al. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial // Br J Nutr. 2012. 107(7):1017–1027.

Ćilerdžić J. L. et al. Neuroprotective Potential and Chemical Profile of Alternatively Cultivated Ganoderma lucidum Basidiocarps // Chem Biodivers. 2018. 15(5):e1800036.

Cong M. et al. A multi-center survey on dietary knowledge and behavior among inpatients in oncology department // Support Care Cancer. 2018. 26(7):2285–2292.

Cui X. Y et al. Extract of Ganoderma lucidum prolongs sleep time in rats // J Ethnopharmacol. 2011. 139(3):796–800.

Das A. et al. Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth // Clin Transl Oncol. 2020. 22(7):1138–1145.

Delzenne N. M., Bindels L. B. Gut microbiota: Ganoderma lucidum, a new prebiotic agent to treat obesity? // Nat Rev Gastroenterol Hepatol. 2015. 12(10):553–554.

Donatini B. Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: a preliminary clinical trial // Int J Med Mushrooms. 2014. 16(5):497–498.

Eo S. K. et al. Antiherpetic activities of various protein bound polysaccharides isolated from Ganoderma lucidum // J Ethnopharmacol. 1999. 68(1–3):175–181.

Eo S. K. et al. Antiviral activities of various water and methanol soluble substances isolated from Ganoderma lucidum // J Ethnopharmacol. 1999. 68(1–3):129–136.

Fatmawati S. et al. Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum // Phytomedicine. 2011. 18(12):1053–1055.

Futrakul N. et al. Treatment with vasodilators and crude extract of Ganoderma lucidum suppresses proteinuria in nephrosis with focal segmental glomerulosclerosis // Nephron. 2002. 92(3):719–720.

Gao Y. et al. Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat // Life Sci. 2002. 72(6):731–745.

Geng X. et al. Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases // Adv Pharmacol. 2020. 87:257–276.

Guo W. L. et al. Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet // Food Funct. 2020. 11(8):6818–6833.

Gurovic M. S. V. et al. DNA damaging potential of Ganoderma lucidum extracts // J Ethnopharmacol. 2018. 217:83–88.

Hassan H. M. et al. Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum: Theoretical and Experimental Study // Drug Des Devel Ther. 2020. 14:2335–2353.

Heleno S. A. et al. Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters // Food Chem Toxicol. 2013. 58:95–100.

Heleno S. A. et al. Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters // Food Chem Toxicol. 2013. 58:95–100.

Heriansyah T. et al. Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model // Vasc Health Risk Manag. 2019. 15:419–427.

Hernández-Márquez E. et al. Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher Basidiomycetes) on transformed cells by human papillomavirus // Int J Med Mushrooms. 2014. 16(2):179–187.

Hijikata Y. et al. Effect of an herbal formula containing Ganoderma lucidum on reduction of herpes zoster pain: a pilot clinical trial // Am J Chin Med. 2005. 33(4):517–523.

Ho Y. W et al. Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast // Mol Cell Biochem. 2007. 301(1–2):173–179.

Hossen M. S et al. Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran-Induced Toxicity in Rats // Evid Based Complement Alternat Med. 2018. 2018:6254929.

Hsieh T. C., Wu J. M. Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3 // Int J Mol Med. 2011. 28(6):1065–1069.

Hsu P. L. et al. Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by Alleviating Disturbed Flow-Induced Oxidative Stress and Inflammation // Oxid Med Cell Longev. 2018. 2018:3491703.

Hu S. et al. Ganoderma lucidum polysaccharide inhibits UVB-induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways // J Cell Physiol. 2019. 234(5):7330–7340.

Hu Z. et al. Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury // Cytokine. 2020. 127:154917.

Huang S. et al. Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease // Stem Cell Reports. 2016. 8(1):84–94.

Huang S. Q., Ning Z. X. Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity // Int J Biol Macromol. 2010. 47(3):336–341.

Jan J. T. et al. Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection // Proc Natl Acad Sci U S A. 2021. 118(5):e2021579118.

Jan R. H. et al. Immuno-modulatory activity of Ganoderma lucidum-derived polysacharide on human monocytoid dendritic cells pulsed with Der p 1 allergen // BMC Immunol. 2011. 12:31.

Jang K. J. et al. Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells // J Acupunct Meridian Stud. 2010. 3(1):24–31.

Jeitler M. et al. Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review // Front Pharmacol. 2020. 11:580656.

Ji Z. et al. Induction of apoptosis in the SW620 colon carcinoma cell line by triterpene-enriched extracts from Ganoderma lucidum through activation of caspase-3 // Oncol Lett. 2011. 2(3):565–570.

Jiang D. et al. Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells // Oncol Rep. 2017. 37(1):594–600.

Jiang J. et al. Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity // Int J Oncol. 2011. 38(6):1675–1682.

Jiang L. et al. Ganoderma lucidum polysaccharide reduces melanogenesis by inhibiting the paracrine effects of keratinocytes and fibroblasts via IL-6/STAT3/FGF2 pathway // J Cell Physiol. 2019. 234(12):22799–22808.

Jiang Y et al. Overview of Ganoderma sinense polysaccharide-an adjunctive drug used during concurrent Chemo/Radiation therapy for cancer treatment in China // Biomed Pharmacother. 2017. 96:865–870.

Jiao C. et al. The effect of Ganodermalucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation // Aging (Albany NY). 2020. 12(14):14125–14140.

Jin X. et al. Ganoderma lucidum (Reishi mushroom) for cancer treatment // Cochrane Database Syst Rev. 2016. 4(4):CD007731.

Katagata Y., Sasaki F. Antiproliferative activity of extracts prepared from three species of Reishi on cultured human normal and tumor cell lines // Mol Med Rep. 2010. 3(1):179–184.

Kim T. H. et al. Induction of apoptosis in MCF‑7 human breast cancer cells by Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelium) // Mol Med Rep. 2016. 13(2):1243–1249.

Kim Y. S. et al. Antiherpetic activities of acidic protein bound polysacchride isolated from Ganoderma lucidum alone and in combinations with interferons // J Ethnopharmacol. (2000. 72(3):451–458.

Kong M. et al. Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice // Int J Immunopathol Pharmacol. 2019. 33:2058738419869489.

Kubota A. et al. Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine // J Ethnopharmacol. 2018. 214:240–243.

Kumaran S et al. Studies on screening, isolation and purification of a fibrinolytic protease from an isolate (VK12) of Ganoderma lucidum and evaluation of its antithrombotic activity // Med Mycol J. 2011. 52(2):153–162.

Kuypers K. P. C. Self-Medication with Ganoderma lucidum ("Reishi") to Combat Parkinson's Disease Symptoms: A Single Case Study // J Med Food. 2021. 24(7):766–773.

Kwok Y. et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers // Anesth Analg. 2005. 101(2):423–426.

Lai C. Y. et al. Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro // Vaccine. 2010. 28(31):4945–4954.

Lee I. et al. Lanostane triterpenes from Ganoderma lucidum suppress the adipogenesis in 3T3-L1 cells through down-regulation of SREBP-1c // Bioorg Med Chem Lett. 2010. 20(18):5577–5581.

Lee M. K. et al. Ergosta-7,22-diene-2β,3α,9α-triol from the fruit bodies of Ganoderma lucidum induces apoptosis in human myelocytic HL-60 cells // Phytother Res. 2011. 25(11):1579–1585.

Lee S. J. et al. Novel Antihypertension Mechanism of β-Glucan by Corin and ANP-Mediated Natriuresis in Mice // Mycobiology. 2020. 48(5):399–409.

Leggett S. et al. The impact of complementary and alternative medicines on cancer symptoms, treatment side effects, quality of life, and survival in women with breast cancer--a systematic review // Nutr Cancer. 2015. 67(3):373–391.

Lei X et al. Recombinant Ganoderma lucidum Immunomodulatory Protein Improves the Treatment for Chemotherapy-Induced Neutropenia // Front Pharmacol. 2020. 11:956.

Levin R. M. et al. Effects of Ganoderma Lucidum shell-broken spore on oxidative stress of the rabbit urinary bladder using an in vivo model of ischemia/reperfusion // Mol Cell Biochem. 2017. 435(1–2):25–35.

Li C. et al. Inhibitory effects of Ganoderma lucidum pharmacopuncture on atopic dermatitis induced by capsaicin in rats // J Dermatol Sci. 2015. 80(3):212–214.

Li K. et al. Three kinds of Ganoderma lucidum polysaccharides attenuate DDC-induced chronic pancreatitis in mice // Chem Biol Interact. 2012. 247:30–38.

Li K. et al. The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo // Oncol Rep. 2017. 38(5):2803–2813.

Li P. et al. Triterpenoids from Ganoderma lucidum and their cytotoxic activities // Nat Prod Res. 2013. 27(1):17–22.

Liang C. et al. Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y // Eur J Med Chem. 2019. 174:130–141.

Liang Z. et al. Hypolipidemic, Antioxidant, and Antiapoptotic Effects of Polysaccharides Extracted from Reishi Mushroom, Ganoderma lucidum (Leysser: Fr) Karst, in Mice Fed a High-Fat Diet // J Med Food. 2018. 21(12):1218–1227.

Liu C. et al. Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients // Int Immunopharmacol. 2015. 27(2):224–231.

Liu H. et al. A recombinant protein rLZ-8, originally extracted from Ganoderma lucidum, ameliorates OVA-induced lung inflammation by regulating Th17/Treg balance // J Leukoc Biol. 2020. 108(2):531–545.

Liu R. M. et al. Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: Involvement of oxidative stress and antioxidant protective system // Chem Biol Interact. 2015. 240:134–144.

Liu W. et al. Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum // Int J Biol Macromol. 2010. 46(4):451–457.

Liu W. et al. Ganoderma triterpenoids attenuate tumour angiogenesis in lung cancer tumour-bearing nude mice // Pharm Biol. 2020. 58(1):1061–1068.

Liu Y. H. et al. Effectiveness of Dp2 nasal therapy for Dp2- induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator // J Microbiol Immunol Infect. 2003. 36(4):236–242.

Liu Y. J. et al. The polysaccharides from Ganoderma lucidum: Are they always inhibitors on human hepatocarcinoma cells? // Carbohydr Polym. 2012. 90(3):1210–1215.

Liu Z. et al. Adjuvanticity of Ganoderma lucidum polysaccharide liposomes on porcine circovirus type-II in mice // Int J Biol Macromol. 2019. 141:1158–1164.

Lu C. C. et al. Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity // Innate Immun. 2016. 22(7):522–533.

Lu J. H. et al. The Novel Herbal Cocktail AGA Alleviates Oral Cancer through Inducing Apoptosis, Inhibited Migration and Promotion of Cell Cycle Arrest at SubG1 Phase // Cancers (Basel). 2020. 12(11):3214.

Lu S. Y. et al. Isolation of benzolactones, Ganodumones A-F from Ganoderma lucidum and their antibacterial activities // Bioorg Chem. 2020. 98:103723.

Lu Y. Z. et al. Effectiveness of Ganoderma lucidum preparation in treating simian acquired immune deficiency syndrome // Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2011. 33(3):318–324.

Ma H. T. et al. Anti-diabetic effects of Ganoderma lucidum // Phytochemistry. 2015. 114:109–113.

Ma J. et al. Cellular and molecular mechanisms of the Ganoderma applanatum extracts induces apoptosis on SGC-7901 gastric cancer cells // Cell Biochem Funct. 2011. 29(3):175–182.

Mallard B. et al. Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake // PLoS One. 2019. 14(11):e0224740.

Matsuzaki H. et al. Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats // BMC Complement Altern Med. 2013. 13:370.

Meneses M. E et al. Hypocholesterolemic Properties and Prebiotic Effects of Mexican Ganoderma lucidum in C57BL/6 Mice // PLoS One. 2016. 11(7):e0159631.

Min-Chang G. et al. Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 β and TNF- α , Oxidative Stress, and NF- κ B Activation in Ovalbumin-Induced Asthmatic Mice // Evid Based Complement Alternat Med. 2014. 2014:182817.

Mishra J. et al. Phenolic Rich Fractions from Mycelium and Fruiting Body of Ganoderma lucidum Inhibit Bacterial Pathogens Mediated by Generation of Reactive Oxygen Species and Protein Leakage and Modulate Hypoxic Stress in HEK 293 Cell Line // Adv Pharmacol Sci. 2018. 2018:6285615.

Nascimento C. P et al. Ganoderma lucidum Ameliorates Neurobehavioral Changes and Oxidative Stress Induced by Ethanol Binge Drinking // Oxid Med Cell Longev. 2020. 2020:2497845.

Noguchi M. et al. Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study // Asian J Androl. 2008. 10(4):651–658.

Ogidi O. C., Oyetayo V. O. Phytochemical property and assessment of antidermatophytic activity of some selected wild macrofungi against pathogenic dermatophytes // Mycology. 2016. 7(1):9–14.

Özevren H. et al. Ganoderma Lucidum Protects Rat Brain Tissue Against Trauma-Induced Oxidative Stress // Korean J Neurotrauma. 2017. 13(2):76–84.

Pan D. et al. Structural characterization and bioactivity evaluation of an acidic proteoglycan extract from Ganoderma lucidum fruiting bodies for PTP1B inhibition and anti-diabetes // Biopolymers. 2014. 101(6):613–623.

Park J. H. et al. Ganoderma lucidum Pharmacopuncture for the Treatment of Acute Gastric Ulcers in Rats // J Pharmacopuncture. 2014. 17(3):40–49.

Parravano M. et al. Effects of Macuprev® Supplementation in Age-Related Macular Degeneration: A Double-Blind Randomized Morpho-Functional Study Along 6 Months of Follow-Up // Adv Ther. 2019. 36(9):2493–2505.

Phan C. W. et al. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism // Crit Rev Biotechnol. 2015. 35(3):355–368.

Pinweha S. et al. The signaling cascades of Ganoderma lucidum extracts in stimulating non-amyloidogenic protein secretion in human neuroblastoma SH-SY5Y cell lines // Neurosci Lett. 2008. 448(1):62–66.

Roda E. et al. Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model // Int J Mol Sci. 2020. 21(10):3479.

Ruan L. et al. The antiresoptive effects of recombinant Lingzhi-8 protein against retinoic acid-induced osteopenia // Eur J Pharmacol. 2019. 863:172669.

Rubel R et al. Medicinal mushroom Ganoderma lucidum (Leyss: Fr) Karst. triggers immunomodulatory effects and reduces nitric oxide synthesis in mice // J Med Food. 2010. 13(1):142–148.

Sa-Ard P. et al. Antioxidant, antibacterial and DNA protective activities of protein extracts from Ganoderma lucidum // J Food Sci Technol. 2015. 52(5):2966–2973.

Sargowo D. et al. The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients // Indian Heart J. 2017. 70(5):608–614.

Saylam Kurtipek G et al. Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom) // Dermatol Ther (Heidelb). 2016. 6(1):105–109.

Shaher F. et al. Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study // Diabetes Metab Syndr Obes. 2020. 13:4809–4822.

Shao C. S. et al. Ganoderic acid D induces synergistic autophagic cell death except for apoptosis in ESCC cells // J Ethnopharmacol. 2020. 262:113213.

Sharma P. et al. Pharmacological effects of Ganoderma lucidum extract against high-altitude stressors and its subchronic toxicity assessment // J Food Biochem. 2019. 43(12):e13081.

Sharma P., Tulsawani R. Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox homeostasis // Sci Rep. 2020. 10(1):8944.

Shen C. et al. Therapeutic effects of nanogel containing triterpenoids isolated from Ganoderma lucidum (GLT) using therapeutic ultrasound (TUS) for frostbite in rats // Drug Deliv. 2016. 23(8):2643–2650.

Sheng F. et al. Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo // Nutrients. 2019. 12(1):85.

Shevelev O. B. et al. Neurometabolic Effect of Altaian Fungus Ganoderma lucidum (Reishi Mushroom) in Rats Under Moderate Alcohol Consumption // Alcohol Clin Exp Res. 2015. 39(7):1128–1136.

Shevelev O. B. et al. Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain // Phytomedicine. 2018. 41:1–6.

Shi M. et al. Antioxidant and immunoregulatory activity of Ganoderma lucidum polysaccharide (GLP) // Carbohydr Polym. 2013. 95(1):200–206.

Shimojo Y. et al. Effect of Ganoderma lucidum extract on adipocyte differentiation and adiponectin gene expression in the murine pre-adipocyte cell line, 3T3-L1 // Phytother Res. 2011. 25(2):202–207.

Smina T. P. et al. Protection of radiation induced DNA and membrane damages by total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst // Chem Biol Interact. 2015. 233:1–7.

Smina T. P. et al. Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals // Mutat Res Genet Toxicol Environ Mutagen. 2016. 813:45–51.

Socala K. et al. Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice // Int J Med Mushrooms. 2019. 17(3):209–218.

Son H. U. et al. The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis // Int J Mol Med. 2017. 39(5):1233–1241.

Song Y. S. et al. Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum // J Ethnopharmacol. 2004. 90(1):17–20.

Su H. G. et al. Lanostane triterpenoids with anti-inflammatory activities from Ganoderma lucidum // Phytochemistry. 2020. 173:112256.

Sudheesh N. P. et al. Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat // Biogerontology. 2009. 10(5):627–636.

Sudheesh N. P. et al. Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice // Clin Nutr. 2010. 29(3):406–412.

Sun L. X. et al. Ganoderma lucidum polysaccharides antagonize the suppression on lymphocytes induced by culture supernatants of B16F10 melanoma cells // J Pharm Pharmacol. 2011. 63(5):725–735.

Sun L. X. et al. Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides // Cell Physiol Biochem. 2014. 33(2):289–299.

Sun X. et al. Syntheses of new rare earth complexes with carboxymethylated polysaccharides and evaluation of their in vitro antifungal activities // Carbohydr Polym. 2014. 113:194–199.

Tang W. et al. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia // J Med Food. 2005. 8(1):53–58.

Tel G. et al. Antioxidant and anticholinesterase activities of five wild mushroom species with total bioactive contents // Pharm Biol. 2015. 53(6):824–830.

Thyagarajan-Sahu A. et al. ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK // BMC Complement Altern Med. 2011. 11:74.

Tsuk S et al. Clinical Effects of a Commercial Supplement of Ophiocordyceps sinensis and Ganoderma lucidum on Cognitive Function of Healthy Young Volunteers // Int J Med Mushrooms. 2017. 19(8):667–673.

Vazirian M. et al. Antimicrobial effect of the Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher Basidiomycetes) and its main compounds // Int J Med Mushrooms. 2014. 16(1):77–84.

Vitak T. Y. et al. The Effect of the Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes) on the Erythron System in Normal and Streptozotocin-Induced Diabetic Rats // Int J Med Mushrooms. 2015. 17(3):277–286.

Wang C. et al. Polysaccharide peptide isolated from grass-cultured Ganoderma lucidum induces anti-proliferative and pro-apoptotic effects in the human U251 glioma cell line // Oncol Lett. 2018. 15(4):4330–4336.

Wang C. et al. Triterpenes and Aromatic Meroterpenoids with Antioxidant Activity and Neuroprotective Effects from Ganoderma lucidum // Molecules. 2019. 24(23):4353.

Wang G. H. et al. Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease: A pilot study // Medicine (Baltimore). 2018. 97(19):e0636.

Wang H., Ng T. B. Ganodermin, an antifungal protein from fruiting bodies of the medicinal mushroom Ganoderma lucidum // Peptides. 2006. 27(1):27–30.

Wang S. Q et al. Intervention effects of ganoderma lucidum spores on epileptiform discharge hippocampal neurons and expression of neurotrophin-4 and N-cadherin // PLoS One. 2013. 8(4):e61687.

Wang S. Q et al. Anti-epileptic effect of Ganoderma lucidum polysaccharides by inhibition of intracellular calcium accumulation and stimulation of expression of CaMKII α in epileptic hippocampal neurons // PLoS One. 2014. 9(7):e102161.

Wang W. J. et al. Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma // Biomed Res Int. 2015. 2015:604385.

Wei B. et al. Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides // J Immunol Res. 2018. 2018:2906494.

Wei J. C. et al. Chemical characteristics of the fungus Ganoderma lucidum and their inhibitory effects on acetylcholinesterase // J Asian Nat Prod Res. 2018. 20(10):992–1001.

Weng C. J., Yen G. C. The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis // Clin Exp Metastasis. 2010. 27(5):361–369.

Wicks S. M. et al. Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial // Am J Chin Med. 2007. 35(3):407–414.

Wihastuti T. A., Heriansyah T. The inhibitory effects of polysaccharide peptides (PsP) of Ganoderma lucidum against atherosclerosis in rats with dyslipidemia // Heart Int. 2017. 12(1):e1–e7.

Wu J. R. et al. (2015) Preclinical trials for prevention of tumor progression of hepatocellular carcinoma by LZ-8 targeting c-Met dependent and independent pathways // PLoS One. 10(1):e0114495.

Wu X. et al. Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum // Oncol Lett. 2021. 21(1):34.

Wu Y. L. et al. Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects // J Agric Food Chem. 2019. 67(18):5147–5158.

Xiao C. et al. Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice // Arch Pharm Res. 2012. 35(10):1793–1801.

Xiao C. et al. Hypoglycemic mechanisms of Ganoderma lucidum polysaccharides F31 in db/db mice via RNA-seq and iTRAQ // Food Funct. 2018. 9(12):6495–6507.

Xie L et al. The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model // BMC Complement Altern Med. 2017. 17(1):511.

Yang G. et al. Ganoderma lucidum polysaccharide exerts anti-tumor activity via MAPK pathways in HL-60 acute leukemia cells // J Recept Signal Transduct Res. 2016. 36(1):6–13.

Yang Q. et al. HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax, Bcl-2 expression // Int J Biol Macromol. 2010. 46(2):167–172.

Yang Y. et al. Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer // Biosci Biotechnol Biochem. 2017. 81(9):1796–1804.

Yarmohammadi F et al. Natural compounds against doxorubicin-induced cardiotoxicity: A review on the involvement of Nrf2/ARE signaling pathway // Phytother Res. 2021. 35(3):1163–1175.

Ye L et al. Purification, NMR study and immunostimulating property of a fucogalactan from the fruiting bodies of Ganoderma lucidum // Planta Med. 2008. 74(14):1730–1734.

Ye W. Y et al. Estrogenic activities of compound GL-1, isolated from Ganoderma lucidum // Nat Prod Res. 2020. 9:1–5.

Yu C et al. UPLC-MS-based serum metabolomics reveals protective effect of Ganoderma lucidum polysaccharide on ionizing radiation injury // J Ethnopharmacol. 2020. 258:112814.

Yu N. et al. Ganoderma lucidum Triterpenoids (GLTs) Reduce Neuronal Apoptosis via Inhibition of ROCK Signal Pathway in APP/PS1 Transgenic Alzheimer's Disease Mice // Oxid Med Cell Longev. 2020. 2020:9894037.

Yuan S. et al. Ganoderma lucidum Rhodiola compound preparation prevent D-galactose-induced immune impairment and oxidative stress in aging rat model // Sci Rep. 2020. 10(1):19244.

Yuen J. W. M. et al. Tumor inhibitory effects of intravesical Ganoderma lucidum instillation in the syngeneic orthotopic MB49/C57 bladder cancer mice model // J Ethnopharmacol. 2018. 223:113–121.

Yuen J. W., Gohel M. D. The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack // J Ethnopharmacol. 2008. 118(2):324–330.

Zeng P. et al. Chemical, biochemical, preclinical and clinical studies of Ganoderma lucidum polysaccharide as an approved drug for treating myopathy and other diseases in China // J Cell Mol Med. 2018. 22(7):3278–3297.

Zeng Q. et al. Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging // Mol Med Rep. 2017. 15(1):111–116.

Zhan L et al. Prophylactic Use of Ganoderma lucidum Extract May Inhibit Mycobacterium tuberculosis Replication in a New Mouse Model of Spontaneous Latent Tuberculosis Infection // Front Microbiol. 2016. 6:1490.

Zhang B. et al. Inhibitory activities of some traditional Chinese herbs against testosterone 5α-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice // J Ethnopharmacol. 2016. 177:1–9.

Zhang J. et al. Extraction, characterization and antioxidant activity of polysaccharides of spent mushroom compost of Ganoderma lucidum // Int J Biol Macromol. 2015. 82:432–439.

Zhang Q. H. et al. Ganoderma lucidum Exerts an Anticancer Effect on Human Osteosarcoma Cells via Suppressing the Wnt/β-Catenin Signaling Pathway // Integr Cancer Ther. 2019. 18:1534735419890917.

Zhang R. et al. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation // Evid Based Complement Alternat Med. 2011. 2011:156810.

Zhang W. et al. [Primary study on proteomics about Ganoderma lucidium spores promoting survival and axon regeneration of injured spinal motor neurons in rats] // Zhong Xi Yi Jie He Xue Bao. 2006. 4(3):298–302.

Zhang Y. et al. Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on "living high-training low" // Br J Sports Med. 2008. 42(10):819–822.

Zhao H. B. et al. Polysaccharide extract isolated from ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury // J Pharmacol Sci. 2004. 95(2):294–298.

Zhao R. et al. The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network // Sci Rep. 2018. 8(1):12680.

Zhao W. et al. Antioxidant activities of Ganoderma lucidum polysaccharides and their role on DNA damage in mice induced by cobalt-60 gamma-irradiation // Food Chem Toxicol. 2012. 50(2):303–309.

Zheng L. et al. Apoptosis induced by 9,11‑dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl‑1 dependent // Mol Med Rep. 2018. 18(1):938–944.

Zhong D. et al. Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress // Sci Rep. 2015. 5:16910.

Zhong L. et al. Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials // Front Pharmacol. 2019. 10:703.

Zhonghui Z. et al. Ganoderma lucidum polysaccharides supplementation attenuates exercise-induced oxidative stress in skeletal muscle of mice // Saudi J Biol Sci. 2014. 21(2):119–123.

Zhou H. et al. Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice // Immunopharmacol Immunotoxicol. 2013. 35(3):426–433.

Zhu M. et al. Triterpene antioxidants from ganoderma lucidum // Phytother Res. 1999. 13(6):529–531.

Zhu X. L. et al. Promotion of Myelopoiesis in Myelosuppressed Mice by Ganoderma lucidum Polysaccharides // Front Pharmacol. 2012. 3:20.

Živković L. et al. Antigenotoxic and antioxidant potential of medicinal mushrooms (Immune Assist) against DNA damage induced by free radicals-an in vitro study // Mutat Res Genet Toxicol Environ Mutagen. 2019. 845:403078.