Ингредиенты

Кордицепс обладает противораковой активностью, даёт общефизиологическую поддержку (особенно в пожилом возрасте), укрепляет иммунитет, повышает выносливость за счёт увеличения потребления кислорода, улучшает когнитивные функции и память, налаживает сон и работу половой сферы. Также для кордицепса показаны антивирусные и антибактериальные свойства, гепатопротекторная активность и позитивное влияние на состояние кожи. Мощный энергетик, улучшает работу сердца. В 2020 году для кордицепса вооружённого официально подтверждена прямая активность против COVID-19.

Перечень научных исследований
подтверждающих эффективность ингредиента

An Y. et al. Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats // Lipids Health Dis. 2018. 17(1):276.

Aramwit P. et al. Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity // Nanoscale Res. Lett. 2015. 10:152.

Baik J. S. et al. Cordycepin induces apoptosis in human neuroblastoma SK-N-BE(2)-C and melanoma SK-MEL-2 cells // Indian J. Biochem. Biophys. 2012. 49(2):86–91.

Bi S. et al. Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris // Food Funct. 2018. 9(1):279–293.

Bi S. et al. Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes // Int. J. Biol. Macromol. 2020. 150:261–280.

Cai Z. L. et al. Effects of cordycepin on Y-maze learning task in mice // Eur. J. Pharmacol. 2013. 714(1-3):249–253.

Chaicharoenaudomrung N. et al. Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy // Toxicol. In Vitro. 2018. 46:113–121.

Chen X. et al. Structural analysis and antioxidant activities of polysaccharides from cultured Cordyceps militaris // Int. J. Biol. Macromol. 2013. 58:18–22.

Chou S. M. et al. Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells // Phytomedicine. 2014. 21(12):1516–1524.

Chu H. L. et al. Protective effect of Cordyceps militaris against high glucose-induced oxidative stress in human umbilical vein endothelial cells // Food Chem. 2011. 129(3):871–876.

Dong C. H. et al. A comparative study of the antimicrobial, antioxidant, and cytotoxic activities of methanol extracts from fruit bodies and fermented mycelia of caterpillar medicinal mushroom Cordyceps militaris (Ascomycetes) // Int. J. Med. Mushrooms. 2014. 16(5):485–495.

Dong Y. et al. Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats // Biomed. Res. Int. 2014. 2014:160980.

Dong Y. et al. Purification of polysaccharides from Cordyceps militaris and their anti‑hypoxic effect // Mol. Med. Rep. 2015. 11(2):1312–1317.

Fung J. C. et al. Cordyceps militaris extract stimulates Cl(-) secretion across human bronchial epithelia by both Ca(2+)(-) and cAMP-dependent pathways // J. Ethnopharmacol. 2011. 138(1):201–211.

Guo P. et al. Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase // J. Pharmacol. Sci. 2010. 113(4):395–403.

Han E. S. et al. Cordyceps militaris extract suppresses dextran sodium sulfate-induced acute colitis in mice and production of inflammatory mediators from macrophages and mast cells // J. Ethnopharmacol. 2011. 134(3):703–710.

Han S. et al. 4-Methoxyphenyl (E)-3-(Furan-3-yl) Acrylate Inhibits Vascular Smooth Muscle Cell Proliferation // J. Cardiovasc. Pharmacol. 2020. 76(1):106–111.

He H. et al. Protective effects of Cordyceps extract against UVB‑induced damage and prediction of application prospects in the topical administration: An experimental validation and network pharmacology study // Biomed. Pharmacother. 2020. 121:109600.

He M. T. et al. Protective role of Cordyceps militaris in Aβ1-42-induced Alzheimer's disease in vivo // Food Sci. Biotechnol. 2018. 28(3):865–872.

Hirsch K. R. et al. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation // J. Diet. Suppl. 2017. 14(1):42–53.

Hsu C. H. et al. Effects of the immunomodulatory agent Cordyceps militaris on airway inflammation in a mouse asthma model // Pediatr. Neonatol. 2008. 49(5):171–178.

Hu S. et al. Structural characterisation and cholesterol efflux improving capacity of the novel polysaccharides from Cordyceps militaris // Int. J. Biol. Macromol. 2019. 131:264–272.

Hu Z. et al. Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats // Evid Based Complement Alternat Med. 2013. 2013:840134.

Huang F. et al. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase // PLoS One. 2019. 14(6):e0218449.

Hwang S. et al. Post-ischemic treatment of WIB801C, standardized Cordyceps extract, reduces cerebral ischemic injury via inhibition of inflammatory cell migration // J. Ethnopharmacol. 2016. 186:169–180.

Jang H. J. et al. Cordycepin inhibits human ovarian cancer by inducing autophagy and apoptosis through Dickkopf-related protein 1/β-catenin signaling // Am. J. Transl. Res. 11(11):6890–6906.

Jeong J. W. et al. Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells // Int. Immunopharmacol. 2010. 10(12):1580–1586.

Jeong M. H. et al. In vitro evaluation of Cordyceps militaris as a potential radioprotective agent // Int. J. Mol. Med. 2014. 34(5):1349–1357.

Jo W. S. et al. The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage // Mycobiology. 2010. 38(1):46–51.

Kang H. J. et al. Cordyceps militaris Enhances Cell-Mediated Immunity in Healthy Korean Men // J. Med. Food. 2015. 18(10):1164–1172.

Kim J. et al. Cordyceps militaris mushroom and cordycepin inhibit RANKL-induced osteoclast differentiation // J. Med. Food. 2015. 18(4):446–452.

Kim S. B. et al. Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL/6J mice // J. Ethnopharmacol. 2014. 151(1):478–484.

Ko K. M., Leung H. Y. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs // Chin. Med. 2007. 2:3.

Kopalli S. R. et al. Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats // Nutrients. 2019. 11(4):906.

Lee D. et al. The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and its Mechanism: An Investigation Using Network Pharmacology-Based Analysis // Biomolecules. 2019. 9(9):414.

Lee D. H. et al. Cordycepin-Enriched WIB801C from Cordyceps militaris Inhibits Collagen-Induced [Ca(2+)]i Mobilization via cAMP-Dependent Phosphorylation of Inositol 1, 4, 5-Trisphosphate Receptor in Human Platelets // Biomol. Ther. (Seoul). 2014. 22(3):223–231.

Lee H. H. et al. Anti-influenza effect of Cordyceps militaris through immunomodulation in a DBA/2 mouse model // J. Microbiol. 2014. 52(8):696–701.

Lee H. H. et al. Involvement of autophagy in cordycepin-induced apoptosis in human prostate carcinoma LNCaP cells // Environ. Toxicol. Pharmacol. 2014. 38(1):239–250.

Lee J. S., Hong E. K. Immunostimulating activity of the polysaccharides isolated from Cordyceps militaris // Int. Immunopharmacol. 2011. 11(9):1226–1233.

Li Z. et al. Cordyceps militaris extract attenuates D-galactose-induced memory impairment in mice // J. Med. Food. 2012. 15(12):1057–1063.

Lin W. H. et al. Improvement of sperm production in subfertile boars by Cordyceps militaris supplement // Am. J. Chin. Med. 2007. 35(4):631–641.

Liu S. et al. Cordyceps Militaris Alleviates Severity of Murine Acute Lung Injury Through miRNAs-Mediated CXCR2 Inhibition // Cell Physiol. Biochem. 2015. 36(5):2003–2011.

Luo C. et al. Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms // Pharmacol. Res. 2019. 148:104409.

Mollah M. L. et al. Cordyceps militaris Grown on Germinated Soybean Induces G2/M Cell Cycle Arrest through Downregulation of Cyclin B1 and Cdc25c in Human Colon Cancer HT-29 Cells // Evid. Based Complement. Alternat. Med. 2012. 2012:249217.

Nasser M. I. et al. Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS // Int. J. Oncol. 2017. 50(3):911–919.

Noh E. et al. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts // Rheumatology (Oxford). 2009. 48(1):45–48.

Ohta Y. et al. In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans // J. Agric. Food Chem. 2007. 55(25):10194–10199.

Olatunji O. J. et al. Cordycepin protects PC12 cells against 6-hydroxydopamine induced neurotoxicity via its antioxidant properties // Biomed. Pharmacother. 2016. 81:7–14.

Park D. K. et al. Antiallergic activity of novel isoflavone methyl-glycosides from Cordyceps militaris grown on germinated soybeans in antigen-stimulated mast cells // J. Agric. Food. Chem. 2012. 60(9):2309–2315.

Park J. M. et al. Cordyceps militaris extract protects human dermal fibroblasts against oxidative stress-induced apoptosis and premature senescence // Nutrients. 2014. 6(9):3711–3726.

Peng J. et al. Effects of cordycepin on the microglia-overactivation-induced impairments of growth and development of hippocampal cultured neurons // PLoS One. 2015. 10(5):e0125902.

Quy T. N., Xuan T. D. Xanthine Oxidase Inhibitory Potential, Antioxidant and Antibacterial Activities of Cordyceps militaris (L.) Link Fruiting Body // Medicines (Basel). 2019. 6(1):20.

Reis F. S. et al. The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties // Food Chem. Toxicol. 2013. 62:91–98.

Ruma I. M. et al. Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells // Int. J. Oncol. 2014. 45(1):209–218.

Sellami M. et al. Herbal medicine for sports: a review // J. Int. Soc. Sports Nutr. 2018. 15:14.

Shin S. et al. Immunostimulatory Effects of Cordyceps militaris on Macrophages through the Enhanced Production of Cytokines via the Activation of NF-kappaB // Immune Netw. 2010. 10(2):55–63.

Sohn S. H. et al. Effect of long-term administration of cordycepin from Cordyceps militaris on testicular function in middle-aged rats // Planta Med. 2012. 78(15):1620–1625.

Song J. et al. Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model // Evid. Based Complement. Alternat. Med. 2015. 2015:174616.

Song J. et al. Cordyceps militaris induces tumor cell death via the caspase‑dependent mitochondrial pathway in HepG2 and MCF‑7 cells // Mol. Med. Rep. 2016. 13(6):5132–5140.

Song Q., Zhu Z. Using Cordyceps militaris extracellular polysaccharides to prevent Pb2+-induced liver and kidney toxicity by activating Nrf2 signals and modulating gut microbiota // Food Funct. 2020. 11(10):9226–9239.

Sun T. et al. Cordyceps militaris Improves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway // Oxid. Med. Cell Longev. 2019. 2019:7850863.

Tan L. et al. Anti-inflammatory effects of cordycepin: A review // Phytother. Res. 2020. DOI: 10.1002/ptr.6890.

Tang J. et al. Antioxidant effects of bioactive compounds isolated from cordyceps and their protective effects against UVB-irradiated HaCaT cells // J. Cosmet. Dermatol. 2019. 18(6):1899–1906.

Tianzhu Z. et al. Antidepressant-like effects of cordycepin in a mice model of chronic unpredictable mild stress // Evid. Based Complement. Alternat. Med. 2014. 2014:438506.

Tran N. K. S. et al. Fermented Cordyceps militaris Extract Prevents Hepatosteatosis and Adipocyte Hypertrophy in High Fat Diet-Fed Mice // Nutrients. 2019. 11(5):1015.

Tsai C. H. et al. Finding of polysaccharide-peptide complexes in Cordyceps militaris and evaluation of its acetylcholinesterase inhibition activity // J. Food Drug. Anal. 2014. 23(1):63–70.

Verma A. K. Cordycepin: a bioactive metabolite of Cordyceps militaris and polyadenylation inhibitor with therapeutic potential against COVID-19 // J. Biomol. Struct. Dyn. 2020. 23:1–8.

Wang H. B. et al. Cordycepin ameliorates cardiac hypertrophy via activating the AMPKα pathway // J. Cell. Mol. Med. 2019. 23(8):5715–5727.

Xie W. et al. Cordyceps militaris Fraction induces apoptosis and G2/M Arrest via c-Jun N-Terminal kinase signaling pathway in oral squamous carcinoma KB Cells // Pharmacogn. Mag. 2018. 14(53):116–123.

Xiong Y. et al. Suppression of T-cell activation in vitro and in vivo by cordycepin from Cordyceps militaris // J. Surg. Res. 2013. 185(2):912–922.

Xu G. et al. Study on the effect of regulation of Cordyceps militaris polypeptide on the immune function of mice based on a transcription factor regulatory network // Food Funct. 2020. 11(7):6066–6077.

Xu Y. F. Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming // Int. J. Med. Mushrooms. 2016. 18(12):1083–1092.

Yang C. et al. Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN phosphatase // Biomed. Res. 2017. 38(5):313–320.

Yang J. et al. Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK // Life Sci. 2020. 251:117645.

Yang Q. et al. A novel protein with anti-metastasis activity on 4T1 carcinoma from medicinal fungus Cordyceps militaris // Int. J. Biol. Macromol. 2015. 80:385–391.

Yang X. et al. Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process // Int. Immunopharmacol. 2015. 26(2):401–408.

Ying X. et al. Cordycepin prevented IL-β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes // Int. Orthop. 2014. 38(7):1519–1526.

Yu S. B. et al. Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro // Evid. Based Complement. Alternat. Med. 2018. 2018:5892957.

Yu S. H. et al. Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice // J. Diabetes Res. 2015. 2015:723190.

Yuan G. et al. Improvement of Learning and Memory Induced by Cordyceps Polypeptide Treatment and the Underlying Mechanism // Evid. Based Complement. Alternat. Med. 2018. 2018:9419264.

Zhao H. et al. Antioxidant and Hypoglycemic Effects of Acidic-Extractable Polysaccharides from Cordyceps militaris on Type 2 Diabetes Mice // Oxid. Med. Cell Longev. 2018. 2018:9150807.

Zhao X. et al. Aqueous Extracts of Cordyceps kyushuensis Kob Induce Apoptosis to Exert Anticancer Activity // Biomed. Res. Int. 2018. 2018:8412098.

Zheng Y. et al. Cordyceps polysaccharide ameliorates airway inflammation in an ovalbumin-induced mouse model of asthma via TGF-β1/Smad signaling pathway // Respir. Physiol. Neurobiol. 2020. 276:103412.

Zhong L. et al. Evaluation of anti-fatigue property of the extruded product of cereal grains mixed with Cordyceps militaris on mice // J. Int. Soc. Sports Nutr. 2017. 14:15.

Zhu Z. Y. et al. Synthesis, characterization and antioxidant activity of selenium polysaccharide from Cordyceps militaris // Int. J. Biol. Macromol. 2016. 93(Pt A):1090–1099.