Ингредиенты

Траметес разноцветный — один из самых известных лекарственных трутовиков. Он обладает мощной противораковой активностью (особенно в плане опухолевых процессов в ЖКТ), регулирует аллергические и аутоиммунные процессы, обладает антиоксидантным, антивирусным, антибактериальным и противогрибковым действием, способен к иммуномодуляции, используется при заболеваниях печени и как детоксикант.

Перечень научных исследований
подтверждающих эффективность ингредиента

Bains A., Chawla P. In vitro bioactivity, antimicrobial and anti-inflammatory efficacy of modified solvent evaporation assisted Trametes versicolor extract // 3 Biotech. 2020. 10(9):404.

Benson K. F. et al. The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro // BMC Complement. Altern. Med. 2019. 19(1):342.

Bucić-Kojić A. et al. Enhancement of the anti-inflammatory properties of grape pomace treated by Trametes versicolor // Food Funct. 2020. 11(1):680–688.

Chen C. H. et al. Polysaccharides of Trametes versicolor Improve Bone Properties in Diabetic Rats // J. Agric. Food Chem. 2015. 63(42):9232–9238.

Chong Z. et al. Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes // Cytotechnology. 2018. 70(3):1001–1008.

Chou C. H. et al. Enzymatic hydrolysates obtained from Trametes versicolor polysaccharopeptides protect human skin keratinocyte against AAPH-induced oxidative stress and inflammatory // J. Cosmet. Dermatol. 2019. 18(6):2011–2018.

Coy C. et al. Significant Correlation between TLR2 Agonist Activity and TNF-α Induction in J774.A1 Macrophage Cells by Different Medicinal Mushroom Products // Int. J. Med. Mushrooms. 2015. 17(8):713–722.

Donatini B. Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: a preliminary clinical trial // Int. J. Med. Mushrooms. 2014. 16(5):497–498.

Engel A. L. et al. Protein-bound polysaccharide activates dendritic cells and enhances OVA-specific T cell response as vaccine adjuvant // Immunobiology. 2013. 218(12):1468–1476.

Erjavec I. et al. Mushroom Extracts Decrease Bone Resorption and Improve Bone Formation // Int. J. Med. Mushrooms. 2016. 18(7):559–569.

Guggenheim A. G. et al. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology // Integr. Med. (Encinitas). 2014. 13(1):32–44.

Habibi E. et al. Mycochemical Investigation of the Turkey Tail Medicinal Mushroom Trametes versicolor (Higher Basidiomycetes): A Potential Application of the Isolated Compounds in Documented Pharmacological Studies // Int. J. Med. Mushrooms. 2015. 17(3):255–265.

Habtemariam S. Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy // Biomedicines. 2020. 8(5):135.

Hsieh T. C., Wu J. M. Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by the combination of Coriolus versicolor and Ganoderma lucidum // Int. J. Mol. Med. 2013. 32(1):251–257.

Huang Z. et al. Extracellular and Intracellular Polysaccharide Extracts of Trametes versicolor Improve Lipid Profiles Via Serum Regulation of Lipid-Regulating Enzymes in Hyperlipidemic Mice // Curr. Microbiol. 2020. 77(11):3526–3537.

Hung P. H. et al. Acetylsalicylic acid-like analgesic effects of Trametes versicolor in Wistar rats // Biomed. Pharmacother. 2020. 129:110328.

Janjušević L. et al. Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement // Nat. Prod. Res. 2018. 32(8):963–967.

Jędrzejewski T. et al. Extract from the Coriolus versicolor Fungus as an Anti-Inflammatory Agent with Cytotoxic Properties against Endothelial Cells and Breast Cancer Cells // Int. J. Mol. Sci. 2020. 21(23):9063.

Jin M. et al. Anti-inflammatory activities of the chemical constituents isolated from Trametes versicolor // Nat. Prod. Res. 2019. 33(16):2422–2425.

Knežević A. et al. Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells // ScientificWorldJournal. 2015. 2015:146378.

Knežević A. et al. Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia // PLoS One. 2018. 13(8):e0203064.

Krupodorova T. et al. Antiviral activity of Basidiomycete mycelia against influenza type A (serotype H1N1) and herpes simplex virus type 2 in cell culture // Virol. Sin. 2014. 29(5):284–290.

Lo H. C. et al. Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Mitigate Oxidative Stress, Hyperglycemia, and Hyperlipidemia in Rats with Type 2 Diabetes Mellitus // Int. J. Med. Mushrooms. 2020. 22(5):417–429.

Lu H. et al. TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy // Clin. Cancer Res. 2011. 17(21):6742–6753.

Pallav K. et al. Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial // Gut Microbes. 2014. 5(4):458–467.

Pan W. et al. Oat-Derived β-Glucans Induced Trained Immunity Through Metabolic Reprogramming // Inflammation. 2020. 43(4):1323–1336.

Quayle K. et al. The TLR2 agonist in polysaccharide-K is a structurally distinct lipid which acts synergistically with the protein-bound β-glucan // J. Nat. Med. 2015. 69(2):198–208.

Ramberg J. E. et al. Immunomodulatory dietary polysaccharides: a systematic review of the literature // Nutr. J. 2010. 9:54.

Rašeta M. et al. Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents // Chem. Biodivers. 2020. 17(12):e2000683.

Ricciardi M. R. et al. Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite // Oxid. Med. Cell Longev. 2017. 2017:5061639.

Roca-Lema D. et al. In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes Versicolor and Grifola Frondosa in Colon Cancer Cells // Int J. Med. Sci. 2019. 16(2):231–240.

Silva A. M. et al. Endopolysaccharides from Ganoderma resinaceum, Phlebia rufa, and Trametes versicolor affect differently the proliferation rate of HepG2 cells // Appl. Biochem. Biotechnol. 2013. 169(6):191–192.

Smith H. et al. Filamentous fungi as a source of natural antioxidants // Food Chem. 2015. 185:389–397.

Stamets P. Trametes versicolor (Turkey Tail Mushrooms) and the Treatment of Breast Cancer // Glob. Adv. Health Med. 2012. 1(5):20.

Standish L. J. et al. Breast Cancer Integrative Oncology Care and Its Costs // Integr. Cancer Ther. 2017. 16(1):85–95.

Teng J. F. et al. Potential activities and mechanisms of extracellular polysaccharopeptides from fermented Trametes versicolor on regulating glucose homeostasis in insulin-resistant HepG2 cells // PLoS One. 2018. 13(7):e0201131.

Torkelson C. J. et al. Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer // ISRN Oncol. 2012. 2012:251632.

Wang K. et al. Polysaccharopeptide from Trametes versicolor blocks inflammatory osteoarthritis pain-morphine tolerance effects via activating cannabinoid type 2 receptor // Int. J. Biol. Macromol. 2019. 126:805–810.

Wenner C. A. et al. Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer // Int. J. Oncol. 2012. 40(4):905–913.

Wu J. M. et al. Recent Advances and Challenges in Studies of Control of Cancer Stem Cells and the Gut Microbiome by the Trametes-Derived Polysaccharopeptide PSP (Review) // Int. J. Med. Mushrooms. 2016. 18(8):651–660.

Yu Z. T. et al. Trametes versicolor extract modifies human fecal microbiota composition in vitro // Plant Foods Hum Nutr. 2013. 68(2):107–112.