Ингредиенты

Плоский трутовик — ближайший родственник рейши — сочетает в себе свойства рейши и чаги. Это лекарственный гриб с огромным потенциалом, пока ещё мало известный. Согласно последним научным исследованиям, он обладает иммуномодулирующей и антиоксидантной активностью, снижает уровень стресса (адаптогенность), благотворно влияет на сердечно-сосудистую систему и улучшает самочувствие.

Перечень научных исследований
подтверждающих эффективность ингредиента

Elkhateeb W. A. et al. Ganoderma applanatum secondary metabolites induced apoptosis through different pathways: In vivo and in vitro anticancer studies // Biomed. Pharmacother. 2018. 101:264–277.

Gao Z. et al. The ameliorations of Ganoderma applanatum residue polysaccharides against CCl4 induced liver injury // Int. J. Biol. Macromol. 2019. 137:1130–1140.

Hanyu X. et al. Effect of Ganoderma applanatum polysaccharides on MAPK/ERK pathway affecting autophagy in breast cancer MCF-7 cells // Int. J. Biol. Macromol. 2020. 146:353–362.

Hsu K. D., Cheng K. C. From nutraceutical to clinical trial: frontiers in Ganoderma development // Appl Microbiol Biotechnol. 2018. 102(21):9037–9051.

Jung M. et al. Ganodermycin, a novel inhibitor of CXCL10 expression from Ganoderma applanatum // J. Antibiot. (Tokyo). 2011. 64(10):683–686.

Jung S. H. et al. Inhibitory effects of Ganoderma applanatum on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues // Phytother. Res. 2005. 19(6):477–480.

Karaman M. et al. Medicinal and edible lignicolous fungi as natural sources of antioxidative and antibacterial agents // Phytother. Res. 2010. 24(10):1473–1481.

Kim J. E. et al. Effect of Ganoderma applanatum mycelium extract on the inhibition of adipogenesis in 3T3-L1 adipocytes // J. Med. Food. 2014. 17(10):1086–1094.

Lee S. et al.Aldose reductase inhibitors from the fruiting bodies of Ganoderma applanatum // Biol Pharm Bull. 2005. 28(6):1103–1105.

Liang D. et al. Hypouricemic Effect of 2,5-Dihydroxyacetophenone, a Computational Screened Bioactive Compound from Ganoderma applanatum, on Hyperuricemic Mice // Int J Mol Sci. 2018. 19(5):1394.

Liu X. et al. Pharmacological and anti-tumor activities of ganoderma spores processed by top-down approaches // J. Nanosci. Nanotechnol. 2005. 5(12):2001–2013.

Luo D. et al. Lanostane-type triterpenoids from Ganoderma applanatum and their inhibitory activities on NO production in LPS-induced BV-2 cells // Phytochemistry. 2020. 177:112453.

Luo Q. et al. Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity // Org. Lett. 2015. 17(5):1110–1113.

Ma J. et al. Cellular and molecular mechanisms of the Ganoderma applanatum extracts induces apoptosis on SGC-7901 gastric cancer cells // Cell Biochem. Funct. 2011. 29(3):175–182.

Ma J. Q. et al. Ganoderma applanatum terpenes protect mouse liver against benzo(α)pyren-induced oxidative stress and inflammation // Environ. Toxicol. Pharmacol. 2011. 31(3):460–468.

Moradali M. F. et al. Investigation of potential antibacterial properties of methanol extracts from fungus Ganoderma applanatum // Chemotherapy. 2006. 52(5):241–244.

Nakashima S. et al. Effect of polysaccharides from Ganoderma applanatum on immune responses. I. Enhancing effect on the induction of delayed hypersensitivity in mice // Microbiol. Immunol. 1979. 23(6):501–513.

Osińska-Jaroszuk M. et al. Exopolysaccharide from Ganoderma applanatum as a promising bioactive compound with cytostatic and antibacterial properties // Biomed. Res. Int. 2014. 2014:743812.

Rivera-Mariani F. E. et al. Skin test reactivity of allergic subjects to basidiomycetes' crude extracts in a tropical environment // Med. Mycol. 2011. 49(8):887–891.

Singh R. et al. Evaluation of Antianxiety Potential of Four Ganoderma (Agaricomycetes) Species from India in Mice // Int. J. Med. Mushrooms. 2016. 18(11):991–998.

Sun X. et al. Carboxylate groups play a major role in antitumor activity of Ganoderma applanatum polysaccharide // Carbohydr. Polym. 2015. 123:283–287.

Tsivileva O. et al. Antioxidant Properties of the Artist's Conk Medicinal Mushroom, Ganoderma applanatum (Agaricomycetes), upon Cultivation with para-Substituted Phenolic Compounds and Tea Leaf Extracts // Int. J. Med. Mushrooms. 2018. 20(6):549–560.

Yang B. K. et al. Hypoglycemic effects of Ganoderma applanatum and Collybia confluens exo-polymers in streptozotocin-induced diabetic rats // Phytother. Res. 2007. 21(11):1066–1069.

Yong T. et al. Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9 // Front. Pharmacol. 2018. 8:996.

Zengin G. et al. Two Ganoderma species: profiling of phenolic compounds by HPLC-DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders // Food Funct. 2015. 6(8):2794–2802.

Zhen D. et al. Purification, partial characterization and inducing tumor cell apoptosis activity of a polysaccharide from Ganoderma applanatum // Int. J. Biol. Macromol. 2018. 115:10–17.