Ингредиенты

Гриб-баран обладает выраженными противораковыми свойствами, очищает и запускает поражённую или «ленивую» печень, повышает клеточное здоровье, поддерживает иммунитет и регулирует метаболизм сахара в крови. Обладает подтверждённой прямой противовирусной активностью, в том числе против COVID-19.

Перечень научных исследований
подтверждающих эффективность ингредиента

Alexander B. et al. Induction of cell death in renal cell carcinoma with combination of D-fraction and vitamin C // Integr Cancer Ther. 2013. 12(5):442–448.

Alonso E. N. et al. Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells // Oncotarget. 2018. 9(34):23396–23412.

Aoki H. et al. Grifola frondosa (Maitake) extract activates PPARδ and improves glucose intolerance in high-fat diet-induced obese mice // Biosci. Biotechnol. Biochem. 2018. 82(9):1550–1559.

Bae J. T. et al. Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts // FEMS Microbiol. Lett. 2005. 251(2):347–354.

Bao H. et al. Griflola frondosa (GF) produces significant antidepressant effects involving AMPA receptor activation in mice // Pharm. Biol. 2017. 55(1):299–305.

Chen J. T. et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate // J. Altern. Complement. Med. 2010. 16(12):1295–1299.

Chen Y. et al. Structural characterization and antidiabetic potential of a novel heteropolysaccharide from Grifola frondosa via IRS1/PI3K-JNK signaling pathways // Carbohydr. Polym. 2018. 198:452–461.

Chen Y. et al. Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice // Food Chem Toxicol. 2019. 126:295–302.

Chen Z. et al. Oral administration of Grifola frondosa polysaccharides improves memory impairment in aged rats via antioxidant action // Mol. Nutr. Food Res. 2017. 61(11). DOI: 10.1002/mnfr.201700313

Chien R. C. et al. Anti-Inflammation Properties of Fruiting Bodies and Submerged Cultured Mycelia of Culinary-Medicinal Higher Basidiomycetes Mushrooms // Int. J. Med. Mushrooms. 2016. 18(11):999–1009.

Cui F. et al. Grifola frondosa Glycoprotein GFG-3a Arrests S phase, Alters Proteome, and Induces Apoptosis in Human Gastric Cancer Cells // Nutr. Cancer. 2016. 68(2):267–279.

Ding Y. et al. The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats // Front. Microbiol. 2016. 7:1186.

Ellertsen L. K., Hetland G. An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy // Clin. Mol. Allergy. 2009. 7:6.

Fan L. et al. A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice // Int. J. Med. Mushrooms. 2019. 21(11):1065–1074.

Gu C. Q. et al. Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: synergistic effect of combination with interferon-alpha in HepG2 2.2.15 // Antiviral Res. 2006. 72(2):162–165.

Guo W. L. et al. Hypoglycemic and hypolipidemic mechanism of organic chromium derived from chelation of Grifola frondosa polysaccharide-chromium (III) and its modulation of intestinal microflora in high fat-diet and STZ-induced diabetic mice // Int. J. Biol. Macromol. 2020. 145:1208–1218.

Han C., Cui B. Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation // Inflammation. 2012. 35(4):1269–1275.

Han S. S. et al. Antimetastatic and immunomodulating effect of water extracts from various mushrooms // J. Acupunct. Meridian. Stud. 2009. 2(3):218–227.

He X. et al. Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review // Int. J. Biol. Macromol. 2017. 101:910–921.

Hetland G. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? // Scand. J. Immunol. 2021. 93(1):e12937.

Hong L. et al. The protective effect of MT-α-glucan against streptozotocin (STZ)-induced NIT-1 pancreatic β-cell damage // Carbohydr. Polym. 2013. 92(2):1211–1217.

Horio H., Ohtsuru M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats // J. Nutr. Sci. Vitaminol (Tokyo). 2021. 47(1):57–63.

Hou L. et al. A water-soluble polysaccharide from Grifola frondosa induced macrophages activation via TLR4-MyD88-IKKβ-NF-κB p65 pathways // Oncotarget. 2017. 8(49):86604–86614.

Illana-Esteban C. El hongo maitake (Grifola frondosa) y su potencial terapéutico [The fungus maitake (Grifola frondosa) and its therapeutic potential] // Rev. Iberoam. Micol. 2008. 25(3):141–144.

Jeurink P. V. et al. Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells // Int. Immunopharmacol. 2008. 8(8):1124–1133.

Jiang J., Sliva D. Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells // Int. J. Oncol. 2010. 37(6):1529–1536.

Jiang T. et al. The hypoglycemic and renal protective effects of Grifola frondosa polysaccharides in early diabetic nephropathy // J. Food Biochem. 2020. 44(12):e13515.

Jung K. et al. Effect of medicinal plant extracts on forced swimming capacity in mice // J Ethnopharmacol. 2004. 93(1):75–81.

Kawai J. et al. Ergosterol and its derivatives from Grifolafrondosa inhibit antigen-induced degranulation of RBL-2H3 cells by suppressing the aggregation of high affinity IgE receptors // Bioscience, Biotechnology, and Biochemistry. 2018. 82(10):1803–1811.

Kawai J. et al. Grifola frondosa extract and ergosterol reduce allergic reactions in an allergy mouse model by suppressing the degranulation of mast cells // Bioscience, Biotechnology, and Biochemistry. 2019. 83(12):2280–2287.

Kodama N. et al. Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells // Biol. Pharm. Bull. 2002. 25(12):1647–1650.

Kodama N. et al. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients // J. Med. Food. 2003. 6(4):371–377.

Kodama N. et al. Maitake D-Fraction enhances antitumor effects and reduces immunosuppression by mitomycin-C in tumor-bearing mice // Nutrition. 2005. 21(5):624–269.

Lee J. S. et al. Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling // Exp. Mol. Med. 2010. 42(2):143–154.

Li Q. et al. A novel Se-polysaccharide from Se-enriched G. frondosa protects against immunosuppression and low Se status in Se-deficient mice // Int. J. Biol. Macromol. 2018. 117:878–889.

Li X. et al. The Positive Effects of Grifola frondosa Heteropolysaccharide on NAFLD and Regulation of the Gut Microbiota // Int. J. Mol. Sci. 2019. 20(21):5302.

Lin H. et al. Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro // Int. Immunopharmacol. 2004. 4(1):91–99.

Lin H. et al. Maitake beta-glucan enhances umbilical cord blood stem cell transplantation in the NOD/SCID mouse // Exp. Biol. Med. (Maywood). 2009. 234(3):342–353.

Lin H. et al. Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity // Cancer Immunol. Immunother. 2010. 59(6):885–897.

Lin J. T., Liu W. H. o-Orsellinaldehyde from the submerged culture of the edible mushroom Grifola frondosa exhibits selective cytotoxic effect against Hep 3B cells through apoptosis // J. Agri.c Food Chem. 2006. 54(20):7564–7569.

Ling-Sing Seow S. et al. Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells // BMC Complement. Altern. Med. 2013. 13:157.

Ma X. et al. A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway // Glycoconj. J. 2014. 31(5):355–363.

Ma X. L. et al. Immunomodulatory activity of macromolecular polysaccharide isolated from Grifola frondosa // Chin. J. Nat. Med. 2015. 13(12):906–914.

Mallard B. et al. Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake // PLoS One. 2019. 14(11):e0224740.

Mao G. H. et al. Effect of Grifola frondosa polysaccharide on anti-tumor activity in combination with 5-Fu in Heps-bearing mice // Int. J. Biol. Macromol. 2019. 121:930–935.

Martin K. R. Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment // Nutr. J. 2010. 9:29.

Masuda Y. et al. Inhibitory effect of MD-Fraction on tumor metastasis: involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung vascular endothelial cells // Biol. Pharm. Bull. 2008. 31(6):1104–1108.

Masuda Y. et al. Maitake beta-glucan enhances therapeutic effect and reduces myelosuppression and nephrotoxicity of cisplatin in mice // Int. Immunopharmacol. 2009. 9(5):620–626.

Masuda Y. et al. Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity // J. Leukoc. Biol. 2015. 98(6):1015–1025.

Mori K. et al. Antiatherosclerotic effect of the edible mushrooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipoprotein E-deficient mice // Nutr. Res. 2008. 28(5):335–342.

Obi N. et al. Inhibitory Effect of TNF-alpha Produced by Macrophages Stimulated with Grifola frondosa Extract (ME) on the Growth of Influenza A/Aichi/2/68 Virus in MDCK Cells // Am. J. Chin. Med. 2008. 36(6):1171–1183.

Pan Y. et al. Regulatory effect of Grifola frondosa extract rich in polysaccharides and organic acids on glycolipid metabolism and gut microbiota in rats // Int. J. Biol. Macromol. 2019. 155:1030–1039.

Park H. S. et al. Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice // Biosci. Biotechnol. Biochem. 2015. 79(1):147–154.

Patel D. K. et al. Influence of Maitake (Grifola frondosa) Particle Sizes on Human Mesenchymal Stem Cells and In Vivo Evaluation of Their Therapeutic Potential // Biomed. Res. Int. 2020. 2020:8193971.

Phan C. W. et al. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism // Crit. Rev. Biotechnol. 2015. 35(3):355–368.

Preuss H. G. et al. Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom // Mol. Cell. Biochem. 2007. 306(1–2):105–113.

Preuss H. G. et al. (Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats // Int. J. Med. Sci. 2010. 7(4):169–180.

Preuss H. G. et al. Fraction SX of maitake mushroom favorably influences blood glucose levels and blood pressure in streptozotocin-induced diabetic rats // J. Med. Food. 2012. 15(10):901–908.

Pyo P. et al. Possible immunotherapeutic potentiation with D-fraction in prostate cancer cells // J. Hematol. Oncol. 2008. 1:25.

Roca-Lema D. et al. In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes Versicolor and Grifola Frondosa in Colon Cancer Cells // Int. J. Med. Sci. 2019. 16(2):231–240.

Roldan-Deamicis A. et al. Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice // Cancer Med. 2016. 5(9):2427–2441.

Sabaratnam V. et al. Neuronal health — can culinary and medicinal mushrooms help? // J. Tradit. Complement. Med. 2013. 3(1):62–68.

Sato M. et al. Effect of dietary Maitake (Grifola frondosa) mushrooms on plasma cholesterol and hepatic gene expression in cholesterol-fed mice // J. Oleo Sci. 2013. 62(12):1049–1058.

Seo Y. R. et al. Structural Elucidation and Immune-Enhancing Effects of Novel Polysaccharide from Grifola frondosa // Biomed. Res. Int. 2019. 2019:7528609.

Shen K. P. et al. Effects of Grifola frondosa non-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice // Pharm. Biol. 2015. 53(5). P. 705–709.

Soares R. et al. Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation // J. Med. Food. 2011. 14(6):563–572.

Su C. H. et al. Inhibitory potential of Grifola frondosa bioactive fractions on α-amylase and α-glucosidase for management of hyperglycemia // Biotechnol. Appl. Biochem. 2013. 60(4):446–452.

Su C. H. et al. A (1→6)-Branched (1→4)-β-d-Glucan from Grifola frondosa Inhibits Lipopolysaccharide-Induced Cytokine Production in RAW264.7 Macrophages by Binding to TLR2 Rather than Dectin-1 or CR3 Receptors // J. Nat. Prod. 2020. 83(2):231–242.

Tanaka T. et al. Anti-osteoporotic effects of syringic acid and vanilic acid in the extracts of waste beds after mushroom cultivation // J. Biosci. Bioeng. 2019. 128(5):622–629.

Wesa K. M. et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study // Cancer Immunol. Immunother. 2015. 64(2):237–247.

Wu S. J. et al. Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent // Am. J. Chin. Med. 2013. 41(1):131–144.

Wu S. J. et al. Anti-diabetic effects of Grifola frondosa bioactive compound and its related molecular signaling pathways in palmitate-induced C2C12 cells // J. Ethnopharmacol. 2020. 260:112962.

Xiao C. et al. Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats // Food Funct. 2015. 6(11):3567–3575.

Xu L. et al. A novel iron supplements preparation from Grifola frondosa polysaccharide and assessment of antioxidant, lymphocyte proliferation and complement fixing activities // Int J Biol Macromol. 2018. 108:1148–1157.

Xu T. et al. The cancer preventive effects of edible mushrooms // Anticancer Agents Med. Chem. 2012. 12(10):1255–1263.

Yeh J. Y. et al. Antioxidant properties and antioxidant compounds of various extracts from the edible basidiomycete Grifola frondosa (Maitake) // Molecules. 2011. 16(4):3197–3211.

Yu J. et al. The caspases-dependent apoptosis of hepatoma cells induced by an acid-soluble polysaccharide from Grifola frondosa // Int. J. Biol. Macromol. 2020. 159:364–372.

Yu J. et al. The structural characteristics of an acid-soluble polysaccharide from Grifola frondosa and its antitumor effects on H22-bearing mice // Int. J. Biol. Macromol. 2020. S0141–8130(20):33200–33201.

Zhang C. et al. Antioxidant, antibacterial and anti-aging activities of intracellular zinc polysaccharides from Grifola frondosa SH-05 // Int. J. Biol. Macromol. 2017. 95:778–787.

Zhang Y. et al. Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway // Int. J. Mol. Med. 2017. 40(4):1089–1095.

Zhao C. et al. Structural characterization and antiviral activity of a novel heteropolysaccharide isolated from Grifola frondosa against enterovirus 71 // Carbohydrate Polymers. 2015. 144:382–389.

Zhao F. et al. The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa // Apoptosis. 2017. 22(11):1461–1472.