Ингредиенты

Обыкновенный трутовик — один из старейших лекарственных грибов, с давних пор использовался в медицине народов Северной Евразии. Лабораторные исследования последних лет подтвердили его противораковую, антиоксидантную, иммуномодулирующую, антибактериальную и антивирусную активность. Гриб показал высокую способность к эффективному снижению уровня «плохого» холестерина. Обладает мощными сорбентными и детоксицирующими свойствами, выводит активные радикалы, снижает активность воспалительного процесса.

Перечень научных исследований
подтверждающих эффективность ингредиента

Cheng Z. et al. A derivative of betulinic acid protects human retinal pigment epithelial (rpe) cells from cobalt chloride-induced acute hypoxic stress // Exp. Eye Res. 2019. 180:92–101.

Choe J. H. et al. Methyl 9-oxo-(10E,12E)-octadecadienoate isolated from Fomes fomentarius attenuates lipopolysaccharide-induced inflammatory response by blocking phosphorylation of STAT3 in murine macrophages // Mycobiology. 2015. 43(3):319–326.

Ci X. et al. Betulin exhibits anti-inflammatory activity in lps-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/NRF2-dependent mechanism // Cell Death Dis. 2017. 8:e2798.

Darkal A. K. et al. Unleashing the Biological Potential of Fomes fomentarius via Dry and Wet Milling // Antioxidants (Basel). 2021. 10(2):303.

Dresch P. et al. Fungal strain matters: colony growth and bioactivity of the European medicinal polypores Fomes fomentarius, Fomitopsis pinicola and Piptoporus betulinus // AMB Express. 2015. 5(1):4.

Feng W., Yang J. S. Chemical constituents of Fomes fomentarius (L. ex Fr.) Kickx [article in Chinese] // Zhonghua Yao Hsueh Za Zhi. 2010. 45:1528–1530.

Gao H. L. et al. Immunomodulatory effects of Fomes fomentarius polysaccharides: an experimental study in mice [article in Chinese] // Nan Fang Yi Ke Da Xue Xue Bao. 2009. 29(3):458–461.

Gáper J. et al. Medicinal Value and Taxonomy of the Tinder Polypore, Fomes fomentarius (Agaricomycetes): A Review // Int. J. Med. Mushrooms. 2016. 18(10):851–859.

Grienke U. et al. European medicinal polypores — a modern view on traditional uses // J Ethnopharmacol. 2014. 154(3):564–583.

Huang T. Z. et al. Chemical constituents and antitumor activity of fruiting body of Fomes fomentarius [article in Chinese] // Mycosystema. 2012. 31(5):775–783.

Kim S. H. et al. Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom Fomes fomentarius in human lung carcinoma cell line // Saudi J. Biol. Sci. 2015. 22(4):484–490.

Lee J.-S. Effects of fomes fomentarius supplementation on antioxidant enzyme activities, blood glucose, and lipid profile in streptozotocin-induced diabetic rats // Nutr. Res. 2005. 25(2):187–195.

Lee S. O. et al. Fomes fomentarius Ethanol Extract Exerts Inhibition of Cell Growth and Motility Induction of Apoptosis via Targeting AKT in Human Breast Cancer MDA-MB-231 Cells // Int. J. Mol. Sci. 2019. 20(5):1147.

Papp N. et al. Ethnomycological use of Fomes fomentarius (L.) Fr. and Piptoporus betulinus (Bull.) P. Karst. in Transylvania, Romania // Genet. Resour. Crop. Evol. 2015. 64(1):101–111.

Park Y. M. et al. Anty-inflammatory and anti-nociceptive effects of the methanol extract of Fomes fomentarius // Biol. Pharm. Bull. 2004. 27(10):1588–1593.

Roussel B. et al. History of the therapeutic uses of the tinder polypore, Fomes fomentarius (L.): Fr. [article in French] // Rev. His.t Pharm. (Paris). 2002. 50(336):599–614.

Seniuk O. F. et al. Anti-infective properties of the melanin-glucan complex obtained from medicinal tinder bracket mushroom, Fomes fomentarius (L.: Fr.) Fr. (Aphyllophoromycetideae) // Int. J. Med. Mushrooms. 2011. 13(1):7–18.

Senyuk O. F. et al. Radioprotective influence on Mice DNA of biopolymer complexes from tinder Fomes fomentarius under ionizing radiation in small doses [article in Ukranian] // Yaderna Fyizika ta Energetika. 2014. 15(1):73–81.

Shnyreva A. V. et al. Antiproliferative activity and cytotoxicity of some medicinal wood-destroying fungi // Int. J. Med. Mushrooms. 2018. 20:1–11.

Zang Y. et al. Fomentarols A-D, sterols from the polypore macrofungus Fomes fomentarius // Phytochemistry. 2013. 92:137–145.

Zhang Y. et al. Compositions and anti-tumor activity of Pyropolyporus fomentarius petroleum ether fraction in vitro and in vivo // PLoS One. 2014. 9(10):e109599.

Zhang Y. et al. Chemical compositions and antiproliferation activities of the chloroform fraction from Pyropolyporus fomentarius in K562 cells // Hum. Exp. Toxicol. 2015. 34(7):732–743.